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hyaluronic acid-engineered milk extracellular vesicles
- Development stage
- Preclinical
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Oral (anticipated/research)
01
Overview
Hyaluronic acid-engineered milk extracellular vesicles (HA-milk sEVs) are small extracellular vesicles isolated from cow milk and covalently functionalized with hyaluronic acid (HA) of varying molecular weights. Their primary mechanism is targeting the overexpressed Cluster of Differentiation 44 (CD44) cell surface receptor, which is highly expressed in certain cancer cells, particularly triple-negative breast cancer (TNBC). This functionalization enhances selectivity and cellular uptake via CD44-mediated endocytosis, offering a platform for targeted drug delivery and diagnostic applications in oncology. The vesicles retain the biocompatibility and stability of milk-derived sEVs while providing targeted delivery capabilities due to HA surface modification[1][2].
- Other names
- hyaluronic acid-functionalized milk extracellular vesiclesHA-milk sEVsHA-mExoshyaluronic acid-decorated milk exosomes
02
Targets
CD44 (CD44 antigen)
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