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Hybrid Donor-Acceptor Polymer Particles
- Development stage
- Preclinical
- Lead developer
- Clemson University
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Intraperitoneal
01
Overview
Hybrid Donor-Acceptor Polymer Particles (HDAPPs) are experimental theranostic nanoparticles developed for the detection and treatment of malignancies, specifically disseminated colorectal cancer. These particles are composed of semiconducting polymers that utilize a donor-acceptor electronic configuration to facilitate the conversion of near-infrared (NIR) light into thermal energy. This photothermal property allows for the localized ablation of tumor cells upon laser stimulation. Furthermore, HDAPPs exhibit fluorescent properties that enable intraoperative tumor detection. To improve specificity, these nanoparticles are frequently functionalized with hyaluronic acid (HA), which targets the cancer stem cell marker CD44. Preclinical studies have demonstrated that intraperitoneal administration of HA-functionalized HDAPPs can selectively bind to colorectal cancer tumors and significantly reduce tumor burden through photothermal therapy.
- Other names
- Hybrid Donor-Acceptor Polymer ParticlesHA-HDAPPsSemiconducting Photothermal Polymer Nanoparticles
02
Targets
CD44 (CD44 antigen)
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