hydrochlorothiazide + amiloride

Hydrochlorothiazide + amiloride is a fixed-dose combination of two diuretics used primarily to treat high blood pressure (hypertension) and fluid retention (edema), especially in patients at risk for low potassium levels. Hydrochlorothiazide is a thiazide diuretic that increases the excretion of sodium and water by inhibiting sodium reabsorption in the distal tubules of the kidney, which helps lower blood pressure but can cause potassium loss. Amiloride is a potassium-sparing diuretic that acts on the distal renal tubules to inhibit sodium reabsorption while reducing potassium excretion, thereby counteracting hypokalemia caused by thiazides. The combination provides effective antihypertensive action while minimizing disturbances in serum potassium[1][2][3][4][5][8].

Brand names

ModureticModuretic 5-50Moduretic5-50Moduretic-5-50

Other names

amiloride/hydrochlorothiazideamiloride and hydrochlorothiazideHCTZ/amiloride