hydrocodone + acetaminophen

Hydrocodone + acetaminophen is a fixed-dose combination of the semisynthetic opioid agonist hydrocodone and the non-opioid analgesic and antipyretic acetaminophen (paracetamol). It is widely prescribed for the management of moderate to moderately severe pain when alternative treatments are inadequate. Hydrocodone acts primarily as an agonist at mu-opioid receptors in the central nervous system to alter the perception of and emotional response to pain, while also possessing antitussive properties. Acetaminophen is believed to exert its analgesic and antipyretic effects primarily by inhibiting prostaglandin synthesis in the central nervous system through cyclooxygenase (COX-1 and COX-2) inhibition, as well as potentially modulating the endogenous cannabinoid and vanilloid systems. Originally developed by Knoll Pharmaceuticals in the late 1970s and marketed under the brand name Vicodin, this combination is now available globally under various brand names and generic formulations.

Brand names

AllayAnexsiaBancap HCCeta-PlusCo-GesicComfortpakDolagesicDolorex ForteDuoCetFenalgexHidrocofenHycetHydrocetHydrogesicLorcetLorcet HDLorcet PlusLortabMargesic HMaxidoneNorcoPolygesicStagesicVanacetVerdrocetVicodinVicodin ESVicodin HPXodolZamicetZolvitZydone

Other names

acetaminophen + hydrocodoneacetaminophen + hydrocodone bitartratehydrocodone + paracetamolhydrocodone bitartrate + acetaminophenhydrocodone bitartrate + paracetamolhydrocodone bitartrate/acetaminophenhydrocodone/APAPhydrocodone/acetaminophenhydrocodone/paracetamolparacetamol + hydrocodone