Drug intelligence / Profile preview

hydrocodone bitartrate + aspirin

Development stage
Approved
Modality
Small Molecules
Administration
Oral
01

Overview

Hydrocodone bitartrate + aspirin is a combination prescription analgesic product containing hydrocodone (an opioid pain reliever) and aspirin (a nonsteroidal anti-inflammatory drug). Hydrocodone acts as a full opioid agonist at the μ-opioid receptor in the brain and spinal cord, providing analgesia by altering pain perception and response, while aspirin inhibits prostaglandin synthesis, resulting in anti-inflammatory, analgesic, and antipyretic effects[5]. This product is intended for oral administration only and is reserved for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate[5]. The combination is classified as a Schedule II controlled substance due to the high risk of dependency, abuse, and misuse associated with opioid content[5][8].

Brand names
Lortab ASAAZDONE
Other names
hydrocodone + aspirinhydrocodone and aspirin
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)

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