Drug intelligence / Profile preview

hydrocodone bitartrate + homatropine methylbromide

Development stage
Approved
Lead developer
Endo International
Modality
Small Molecules
Administration
Oral
01

Overview

Hydrocodone bitartrate + homatropine methylbromide is a **combination oral pharmaceutical** used for the **symptomatic relief of cough in adults**. It consists of two active ingredients: **hydrocodone**, a semi-synthetic opioid agonist that acts as a centrally acting antitussive (cough suppressant) by binding to and activating the mu-opioid receptor in the brainstem cough center, and **homatropine methylbromide**, a muscarinic antagonist (anticholinergic) intended to reduce the risk of deliberate opioid overdose by causing undesirable side effects when taken in higher-than-intended amounts. Hydrocodone can cause significant risks including addiction, abuse, respiratory depression, and potential for overdose, while homatropine provides minimal therapeutic effect at recommended doses. Primary indication is **symptomatic relief of cough in adults (age 18 years and older)**; not recommended for pediatric patients under 18 years. The drug is taken by oral route only[1][2][3].

Brand names
HycodanHydrometTussigon
Other names
hydrocodone and homatropinehydrocodone bitartrate and homatropine methylbromide
02

Targets

mAChR (Muscarinic acetylcholine receptors)DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)KOR (Kappa opioid receptor)

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