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hydrocortisone (Neurocrine Biosciences)
- Development stage
- Phase 3
- Lead developer
- Neurocrine Biosciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Hydrocortisone is a synthetic glucocorticoid that serves as the mainstay of replacement therapy for adrenal insufficiency, a condition characterized by inadequate production of endogenous cortisol. This specific pediatric formulation, originally developed as Infacort and now marketed as Alkindi, consists of immediate-release oral granules designed to allow for precise low-dose titration in neonates, infants, and children. By acting as an agonist at the glucocorticoid receptor, hydrocortisone restores physiological levels of the hormone, thereby regulating essential metabolic, immune, and cardiovascular processes. The development of this formulation by Neurocrine UK Limited (formerly Diurnal) addressed a significant unmet need for an age-appropriate delivery mechanism for young patients who require accurate dosing to mimic the natural circadian rhythm of cortisol.
- Brand names
- AlkindiAlkindi SprinkleInfacort
- Other names
- hydrocortisonecortisol
02
Targets
GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)
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