hydrocortisone + fludrocortisone

Hydrocortisone + fludrocortisone is a combination therapy used primarily for the treatment of adrenal insufficiency, such as Addison's disease and congenital adrenal hyperplasia. Hydrocortisone is a synthetic glucocorticoid that mimics cortisol, providing anti-inflammatory and immunosuppressive effects. Fludrocortisone is a synthetic mineralocorticoid structurally related to cortisol but with strong aldosterone-like activity, helping to regulate sodium retention and potassium excretion. The combination replaces both glucocorticoid and mineralocorticoid activity in patients whose adrenal glands do not produce sufficient endogenous corticosteroids. This dual replacement improves prognosis in conditions like catecholamine-resistant septic shock with relative adrenal insufficiency by supporting vascular responsiveness and fluid balance[5][6][8].

Brand names

AstoninAstonin-HCortineffFlorinefeFludrocortison

Other names

hydrocortisone + fludrocortisone acetate