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hydrocortisone + prednisone

Development stage: Unknown
Lead developer: Merck
Modality: Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration: Oral, Intravenous, Topical, Rectal

Overview

A combination of two synthetic corticosteroids (hydrocortisone and prednisone) with anti-inflammatory and immunosuppressive properties. Prednisone is approximately 4-5 times more potent than hydrocortisone in terms of glucocorticoid activity, with a longer duration of action (18-36 hours vs. 8-12 hours). Both medications work by binding to the glucocorticoid receptor, inhibiting pro-inflammatory signals and promoting anti-inflammatory responses.

Targets

GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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