hydrocortisone acetate + bacitracin zinc + neomycin sulfate + polymyxin b

Hydrocortisone acetate + bacitracin zinc + neomycin sulfate + polymyxin b is a topical ophthalmic combination drug formulated as a sterile ointment for steroid-responsive inflammatory ocular conditions in which bacterial infection is present or there is a risk of bacterial infection. The product combines three antibacterial small molecules with a corticosteroid: bacitracin inhibits bacterial cell wall synthesis, polymyxin b disrupts bacterial cell membrane permeability, neomycin inhibits bacterial protein synthesis by binding the bacterial 30S ribosomal subunit, and hydrocortisone acetate activates the glucocorticoid receptor to suppress ocular inflammation. It is used for inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe, including chronic anterior uveitis, conjunctivitis, and corneal injury from chemical, thermal, or radiation burns or foreign body penetration. It is marketed in the United States as Neo-Polycin HC and is also available as a generic ophthalmic ointment from multiple manufacturers.

Brand names

Neo-Polycin HC

Other names

neomycin sulfate + polymyxin b sulfate + bacitracin zinc + hydrocortisone acetate ophthalmic ointmenthydrocortisone acetate + bacitracin zinc + neomycin sulfate + polymyxin b ophthalmic ointment