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hydrocortisone acetate + lidocaine (Aspen Pharmacare)
- Development stage
- Phase 2
- Lead developer
- Aspen Pharma Trading
- Modality
- Small Molecules
- Administration
- Rectal, Topical
01
Overview
Xyloproct is a topical fixed-dose combination medication containing the local anesthetic lidocaine and the corticosteroid hydrocortisone acetate. It is indicated for the symptomatic relief of pain, itching, and inflammation associated with hemorrhoids, anal fissures, proctitis, pruritus ani, and postoperative anorectal discomfort. Lidocaine acts by reversibly blocking voltage-gated sodium channels, thereby inhibiting nerve impulse initiation and conduction to provide rapid local anesthesia. Hydrocortisone acetate acts as a glucocorticoid receptor agonist, suppressing inflammatory pathways to reduce swelling, redness, and itching. Originally developed by Astra AB (now AstraZeneca), the global rights (excluding the US) were acquired by Aspen Pharma in 2016–2017.
- Brand names
- Xyloproct
- Other names
- hydrocortisone acetate + lidocainelidocaine + hydrocortisone acetatelidocaine/hydrocortisone acetate
02
Targets
GR (Glucocorticoid receptor)NaV (Voltage-gated sodium channels)
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