hydrocortisone cypionate

Hydrocortisone cypionate is a synthetic glucocorticoid corticosteroid and a corticosteroid ester. It is the water-insoluble cypionate ester of hydrocortisone and is used primarily for its anti-inflammatory and immunosuppressive properties. When administered orally or topically in equimolar doses to hydrocortisone free alcohol (the parent compound), it exhibits equivalent biological activity. Its mechanism of action involves binding to the glucocorticoid receptor and modulating gene expression to inhibit inflammatory pathways such as phospholipase A2 and NF-kappa B while promoting anti-inflammatory genes like interleukin‑10. Clinically it is indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses as well as certain endocrine disorders.

Brand names

Cortef oral suspension

Other names

hydrocortisone cypionateHydrocortisone cipionateCortisol 21-cyclopentanepropionateCortisol21-cyclopentanepropionateCortisol-21-cyclopentanepropionateHydrocortisone CyclopentylpropionateHydrocortisone cyclopentyl propionateCortisol, 21-cyclopentanepropionateCHEBI:5783[2-\[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,\]...