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Chronocort is a modified-release preparation of hydrocortisone specifically designed to mimic the circadian rhythm of cortisol when given in a twice-daily regimen. It uses multiparticulate technology with an enteric coat that has a pH trigger of 6.8, allowing small bowel dissolution. This formulation enables a more physiologic cortisol replacement therapy for patients with congenital adrenal hyperplasia (CAH) and potentially adrenal insufficiency.
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