Drug intelligence / Profile preview

hydrocortisone sodium phosphate

Development stage
Approved
Lead developer
Advanz Pharma
Modality
Small Molecules
Administration
Intravenous, Intramuscular, Intralesional
01

Overview

Efcortesol is a brand of hydrocortisone sodium phosphate, a water-soluble glucocorticoid corticosteroid. It is formulated as a ready-to-use injectable solution for conditions requiring rapid corticosteroid action, such as acute adrenal insufficiency and severe asthma. As a glucocorticoid receptor agonist, it exerts potent anti-inflammatory and immunosuppressive effects. In clinical research, it has been evaluated as an adjunct to local anesthetics (like bupivacaine) for treating chronic degenerative tendinopathies, including Achilles and patellar tendinopathy, particularly in the BE FIT Study sponsored by the UK Directorate of Defence Rehabilitation.

Brand names
Efcortesol
Other names
hydrocortisone phosphatehydrocortisone 21-phosphatehydrocortisone21-phosphatehydrocortisone-21-phosphatehydrocortisone sodium phosphate
02

Targets

SERPINA6 (Corticosteroid-binding globulin)GR (Glucocorticoid receptor)MR (Mineralocorticoid receptor)

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