hydrocortisone sodium succinate

Hydrocortisone sodium succinate is a highly water-soluble ester of hydrocortisone used as an anti-inflammatory and immunosuppressive glucocorticoid. It acts by mimicking endogenous cortisol, binding to glucocorticoid receptors to modulate gene expression and suppress inflammation and immune responses. This formulation allows for rapid intravenous or intramuscular administration in emergency situations where high blood levels of corticosteroid are needed quickly. It is indicated for severe allergic reactions, dermatologic diseases, endocrine disorders (including adrenocortical insufficiency), gastrointestinal diseases, hematological disorders, neoplastic diseases (as palliative therapy), nervous system conditions (such as cerebral edema), ophthalmic diseases, renal disease (e.g., nephrotic syndrome), respiratory conditions (e.g., asthma exacerbations), rheumatic disorders (e.g., rheumatoid arthritis), and other acute or chronic inflammatory states[1][2][5][6]. Hydrocortisone sodium succinate has both glucocorticoid and mineralocorticoid activity[5].

Brand names

Solu-CortefA-Hydrocort

Other names

hydrocortisone sodium succinate for injectionhydrocortisone succinatepregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, monosodium salt