Drug intelligence / Profile preview

hydrocortisone tertiary-butylacetate

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intraarticular
01

Overview

Hydrocortisone tertiary-butylacetate is a synthetic ester derivative of hydrocortisone, a naturally occurring glucocorticoid hormone. It has been investigated for intra-articular therapy in rheumatic diseases, where it acts as an anti-inflammatory and immunosuppressive agent. Like other corticosteroids, its mechanism of action involves binding to the glucocorticoid receptor and modulating gene expression to suppress inflammation and immune responses. Hydrocortisone derivatives are commonly used for their ability to reduce swelling, redness, and immune activity in various inflammatory conditions[3].

02

Targets

GR (Glucocorticoid receptor)

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