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Hydrolyzed bovine collagen low-molecular-weight peptides are bioactive fragments produced through the enzymatic hydrolysis of bovine type I collagen. These peptides, typically characterized by a molecular weight below 3-5 kDa, are designed to exhibit high bioavailability and specific regenerative properties in connective tissues. In clinical settings, they are administered via ultrasound-guided peritendinous or intra-articular injections to treat musculoskeletal conditions such as partial supraspinatus tendon tears and knee osteoarthritis. The mechanism of action involves stimulating resident cells, such as tenocytes and chondrocytes, to increase the biosynthesis of extracellular matrix components, including type I and type II collagen. This dual action provides both a structural scaffold for tissue repair and biochemical signaling to modulate the local inflammatory environment, thereby promoting the natural healing process of damaged tendons and ligaments.
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