Drug intelligence / Profile preview

hydroxyamphetamine

Development stage
Unknown
Modality
Small Molecules
Administration
Topical, Ophthalmic
01

Overview

Hydroxyamphetamine is an indirectly acting sympathomimetic amine and a derivative of amphetamine, primarily used as a topical ophthalmic agent for diagnostic purposes. Its main clinical use is to induce mydriasis (pupil dilation) during eye examinations and in the diagnosis of conditions such as Horner's syndrome. The drug acts by causing the release of norepinephrine from adrenergic nerve terminals, leading to pupil dilation. Hydroxyamphetamine also has minor activity as a serotonin releasing agent and inhibits monoamine oxidase A (MAO-A), increasing levels of certain neurotransmitters. It is most commonly available in combination with tropicamide under the brand name Paremyd[2][5][6][8].

Brand names
Paremyd
Other names
4-hydroxyamphetamine
02

Targets

NET (Norepinephrine Transporter)TAAR1 (Trace amine-associated receptor 1)SERT (Sodium-dependent serotonin transporter)MAOA (Monoamine oxidase A)

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