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Drug intelligence / Profile preview
hydroxyamphetamine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Topical, Ophthalmic
01
Overview
Hydroxyamphetamine is an indirectly acting sympathomimetic amine and a derivative of amphetamine, primarily used as a topical ophthalmic agent for diagnostic purposes. Its main clinical use is to induce mydriasis (pupil dilation) during eye examinations and in the diagnosis of conditions such as Horner's syndrome. The drug acts by causing the release of norepinephrine from adrenergic nerve terminals, leading to pupil dilation. Hydroxyamphetamine also has minor activity as a serotonin releasing agent and inhibits monoamine oxidase A (MAO-A), increasing levels of certain neurotransmitters. It is most commonly available in combination with tropicamide under the brand name Paremyd[2][5][6][8].
- Brand names
- Paremyd
- Other names
- 4-hydroxyamphetamine
02
Targets
MAOA (Monoamine oxidase A)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)TAAR1 (Trace amine-associated receptor 1)
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