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hydroxyasiaticoside
- Development stage
- Phase 4
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Small Molecules
- Administration
- Oral, Topical
01
Overview
Hydroxyasiaticoside (also known as madecassoside) is a natural pentacyclic triterpenoid saponin isolated from the medicinal plant *Centella asiatica* (Gotu Kola). It possesses potent anti-inflammatory, antioxidant, wound-healing, and skin-barrier-repairing properties. Mechanistically, hydroxyasiaticoside stimulates collagen type I and type III synthesis via the TGF-β/Smad signaling pathway, suppresses pro-inflammatory cytokine production (such as TNF-α, IL-6, and IL-1β) by inhibiting NF-κB and MAPK signaling, and directly binds to targets such as protein kinase C beta (PKCB), serine racemase, and melanocortin 1 receptor (MC1R). It is being clinically evaluated by West China Hospital of Sichuan University as a topical repair cream (often in combination with panthenol) for the treatment of acne-related post-inflammatory erythema, and as oral tablets for sclerotic chronic graft-versus-host disease (cGVHD).
- Brand names
- CicaplastMadecassolRedermic
- Other names
- asiaticoside Ahydroxy centella asiatica glycosidehydroxycentella asiatica glycosidemadecassoside
02
Targets
Aβ (Amyloid-beta peptides and aggregates)MC1R (Melanocortin Type 1 Receptor)JNK (Mitogen-activated protein kinase kinase kinase family)PRKCB (Protein kinase C beta)SRR (Serine racemase)
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