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hydroxychloroquine + azithromycin + zinc + vitamin C + vitamin D3 + n-acetylcysteine + elderberry + quercetin
- Development stage
- Phase 1
- Lead developer
- International Brain Research Foundation
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
This therapeutic regimen, evaluated by the International Brain Research Foundation, is a multi-component combination therapy for the treatment and prevention of COVID-19. It consists of the antimalarial drug hydroxychloroquine, the antibiotic azithromycin, and a suite of dietary supplements including elemental zinc, vitamin C, vitamin D3, n-acetylcysteine, elderberry, and quercetin. The regimen was designed to leverage the hypothesized antiviral and immunomodulatory effects of hydroxychloroquine and azithromycin, alongside the immune-supporting and antioxidant properties of the supplements. Specifically, zinc was included for its potential to inhibit viral replication, while quercetin was intended to act as a zinc ionophore. The regimen was studied in a Phase 1 clinical trial to assess safety and efficacy in reducing the severity of COVID-19 symptoms and preventing infection.
- Other names
- Hydroxychloroquine Regimen for COVID-19 Treatment & Prevention
02
Targets
Bacterial 50S ribosomal subunitRdRp (Coronavirus RNA-dependent RNA polymerase)S1 (SARS-CoV-2 spike S1 subunit)VDR (Vitamin D receptor)TLR7 (Toll-like receptor 7)TLR9 (Toll-like receptor 9)
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