Drug intelligence / Profile preview

hydroxychloroquine + magnesium sulfate + prednisolone

Development stage
Unknown
Lead developer
Sanofi
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

This is a combination of three active pharmaceutical ingredients: - **Hydroxychloroquine** is an antimalarial and disease-modifying anti-rheumatic drug (DMARD) used for malaria, rheumatoid arthritis, and lupus erythematosus. It acts by modulating immune system activity and interfering with lysosomal activity in antigen-presenting cells[1][6]. - **Magnesium sulfate** is an inorganic salt used as an electrolyte replenisher in hypomagnesemia, as a tocolytic agent, anticonvulsant in eclampsia, and for other indications. It works primarily by replacing magnesium ions in the body. - **Prednisolone** is a synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts as an agonist at the glucocorticoid receptor to inhibit pro-inflammatory signals[5]. There are no widely recognized brand or trade names for this specific triple combination; it would be considered an off-label or compounded therapy if prescribed together.

02

Targets

GR (Glucocorticoid receptor)ABCB1 (P-glycoprotein)

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