Drug intelligence / Profile preview

hydroxychloroquine + vorinostat

Development stage: Phase 2
Lead developer: University of Texas Health Science Center at San Antonio
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy consisting of hydroxychloroquine (HCQ) and vorinostat (VOR). Hydroxychloroquine functions as an autophagy inhibitor while vorinostat is a histone deacetylase (HDAC) inhibitor. This combination has been investigated primarily for metastatic colorectal cancer (mCRC) and HIV. The dual mechanism of action leads to autophagy inhibition, accumulation of ubiquitinated proteins, subsequent tumor cell apoptosis, and improved anti-tumor immunity.

Other names: HCQhydroxychloroquinevorinostatSAHAVorinostat and HydroxychloroquineHCQ + Vorinostat

Targets

HDAC1 (Histone Deacetylase 1)HDAC2 (Histone deacetylase 2)HDAC3 (Histone Deacetylase 3)HDAC6 (Histone deacetylase 6)PPT1 (Palmitoyl-protein thioesterase 1)Neuraminidase

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