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Drug intelligence / Profile preview
hydroxydione
- Development stage
- Unknown
- Lead developer
- UCB
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Hydroxydione is a synthetic neuroactive steroid that was previously used as a general anesthetic. It acts primarily as a positive allosteric modulator of the GABA_A receptor, enhancing the inhibitory effects of gamma-aminobutyric acid (GABA) in the central nervous system. Hydroxydione was introduced in the early 1950s under the brand name Viadril for intravenous anesthesia but was later withdrawn from clinical use due to reports of thrombophlebitis and other adverse reactions. It is structurally related to endogenous neurosteroids and represents one of the earliest examples of steroid-based anesthetics.
- Brand names
- Viadril
- Other names
- hydroxydione21-hydroxy-5β-pregnane-3,20-dione
02
Targets
GABRR (GABA-A receptor subunit rho)
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