Drug intelligence / Profile preview

hydroxyethylpromethazine

Development stage
Unknown
Modality
Small Molecules
01

Overview

Hydroxyethylpromethazine is a small molecule drug belonging to the phenothiazine class. It is structurally related to promethazine and shares similar pharmacological properties, likely acting as an antagonist at histamine H1 receptors and possibly other targets such as muscarinic acetylcholine receptors, dopamine receptors, alpha adrenergic receptors, and NMDA receptors. Its primary indication has been investigational; detailed clinical uses are not established in the public domain. As a phenothiazine derivative, it may possess antihistaminic, antiemetic, sedative, and anticholinergic effects[2].

Other names
hydroxyethylpromethazineN-hydroxyethylpromethazinepromethazine hydroxyethylUNII-571559SLAJUNII571559SLAJUNII 571559SLAJ
02

Targets

ADRA2B (α2B)ADRA2C (α2C)HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)CHRM4 (M4)DRD2 (Dopamine D2 Receptor)CHRM3 (M3)CHRM5 (M5)CHRM2 (M2)ADRA2A (α2A)ADRA1B (α1B)ADRA1D (α1D)ADRA1A (α1A)

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