Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
hydroxypipamperone
- Development stage
- Unknown
- Lead developer
- Zhejiang Huahai Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Hydroxypipamperone is a small molecule butyrophenone derivative and the primary active metabolite of the antipsychotic pipamperone. Developed by Zhejiang Huahai Pharmaceutical, it is currently in Phase II clinical development in China for the treatment of major depressive disorder (MDD). Like its parent compound, hydroxypipamperone is characterized by its potent antagonism of 5-hydroxytryptamine receptor 2A (5-HT2A) and moderate antagonism of dopamine D2 receptors. This pharmacological profile suggests potential efficacy in treating depressive symptoms with a lower risk of extrapyramidal side effects compared to traditional antipsychotics. It is administered orally as a hydrochloride salt formulation.
- Other names
- hydroxypipamperone hydrochloridepipamperone-OH
02
Targets
DRD4 (Dopamine D4 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)ADRA2A (α2A)HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)DRD3 (Dopamine receptor D3)
Beyond the preview
Go deeper on hydroxypipamperone.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on hydroxypipamperone.