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hydroxypipamperone
- Development stage
- Phase 2
- Lead developer
- Zhejiang Huahai Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Hydroxypipamperone is a small molecule butyrophenone derivative and the primary active metabolite of the antipsychotic pipamperone. Developed by Zhejiang Huahai Pharmaceutical, it is currently in Phase II clinical development in China for the treatment of major depressive disorder (MDD). Like its parent compound, hydroxypipamperone is characterized by its potent antagonism of 5-hydroxytryptamine receptor 2A (5-HT2A) and moderate antagonism of dopamine D2 receptors. This pharmacological profile suggests potential efficacy in treating depressive symptoms with a lower risk of extrapyramidal side effects compared to traditional antipsychotics. It is administered orally as a hydrochloride salt formulation.
- Other names
- hydroxypipamperone hydrochloridepipamperone-OH
02
Targets
HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)ADRA1A (α1A)ADRA2A (α2A)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)DRD4 (Dopamine D4 Receptor)
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