Drug intelligence / Profile preview

hydroxypropyl guar + propylene glycol + phospholipid

Development stage
Unknown
Lead developer
Alcon
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Ophthalmic, Topical
01

Overview

This is a combination product containing hydroxypropyl guar, propylene glycol, and phospholipid. Hydroxypropyl guar is a nonionic polymer derived from guar gum that acts as a thickening, stabilizing, emulsifying, and film-forming agent in pharmaceutical and cosmetic formulations[1][2][4]. It improves viscosity, provides lubricity, forms protective films on surfaces (such as skin or mucosa), and helps stabilize emulsions. Propylene glycol is commonly used as a solvent and humectant in pharmaceuticals and cosmetics; it enhances moisture retention and can improve the solubility of other ingredients. Phospholipids are amphiphilic molecules often used to enhance drug delivery by forming liposomes or improving emulsion stability; they also contribute to moisturizing properties by mimicking natural cell membrane components. This combination may be formulated for topical use (e.g., artificial tears/eye drops or skin care products) where hydroxypropyl guar provides viscosity and film formation for prolonged retention time on the surface; propylene glycol acts as a humectant/lubricant; phospholipids support emulsion stability or act as penetration enhancers. The mechanism of action is primarily physical—providing lubrication, moisture retention, stabilization of formulations, protection against dehydration/irritation—and not pharmacological in the sense of receptor binding.

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