hydroxythiohomosildenafil

Hydroxythiohomosildenafil is a **synthetic sildenafil analog** and **phosphodiesterase-5 inhibitor** that has been identified primarily as an **undeclared adulterant** in sexual enhancement and erectile dysfunction products rather than as a legitimately developed therapeutic medicine. It is a **small molecule** structurally related to sildenafil, with sulfur substitution in the pyrazolopyrimidine core and a hydroxyethyl substitution on the piperazinyl nitrogen. By inhibiting PDE-5, it is expected to increase cyclic guanosine monophosphate levels, promote smooth muscle relaxation, and increase blood flow in erectile tissue. The compound is mainly relevant as an **analytical reference standard** and public health concern in regulatory and toxicology contexts, and it is not known to have been developed or approved by a legitimate pharmaceutical sponsor for clinical use.

Other names

hydroxythiohomosildenafil