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Drug intelligence / Profile preview
hydroxyurea + azathioprine + alemtuzumab + thiotepa + plerixafor + total body irradiation + cyclophosphamide + sirolimus
- Development stage
- Preclinical
- Lead developer
- Bristol Myers Squibb
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Oral, Intravenous, Subcutaneous, Intrathecal, External Radiation
01
Overview
This is a combination conditioning regimen used in hematopoietic cell transplantation. It includes multiple chemotherapeutic agents (hydroxyurea, azathioprine, thiotepa, cyclophosphamide), an immunosuppressant (sirolimus), a monoclonal antibody (alemtuzumab), a stem cell mobilizer (plerixafor), and radiation therapy (total body irradiation). This intensive combination is likely used for preparing patients with hematologic malignancies or other conditions for stem cell transplantation by depleting bone marrow cells and suppressing the immune system to prevent graft rejection.
02
Targets
CD52 (CD52 Antigen)CXCR4 (C-X-C motif chemokine receptor 4)DNARAC1 (Rac family small GTPase 1)RNR (Ribonucleotide reductase)Mechanistic target of rapamycin complex 1
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