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Drug intelligence / Profile preview
hynic bombesine
- Development stage
- Preclinical
- Lead developer
- Aprin Sama Pharmed
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
Hynic bombesine (HYNIC-bombesin) is a peptide radiopharmaceutical active ingredient developed by Aprin Sama Pharmed. It consists of the bombesin peptide conjugated to the bifunctional chelator 2-hydrazinonicotinamide (HYNIC). Bombesin is a 14-amino acid peptide with high affinity for the gastrin-releasing peptide receptor (GRPR), which is overexpressed in various malignant tumors, including prostate and breast cancers. Hynic bombesine is designed to be readily labeled with radionuclides such as technetium-99m (99mTc) or rhenium-188 (188Re) for diagnostic imaging or targeted radionuclide therapy of GRPR-positive tumors.
- Other names
- 2-hydrazinonicotinamide-bombesin2-hydrazinonicotinamide-bombesineHYNIC-bombesinHYNIC-bombesine
02
Targets
GRPR (Gastrin-releasing peptide receptor)
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