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HYNIC-cRGDfk-NPY
- Development stage
- Preclinical
- Lead developer
- Universidade Presbiteriana Mackenzie
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptides
- Administration
- Intravenous
01
Overview
HYNIC-cRGDfk-NPY is a novel heterobivalent dual-receptor-targeting peptide conjugate designed for the imaging of breast tumors. It consists of a cyclic RGD peptide sequence (cRGDfk) that targets integrin αvβ3 (a marker of tumor angiogenesis) and a neuropeptide Y (NPY) analog that targets neuropeptide Y receptors (specifically Y1R, which is overexpressed in approximately 90% of human breast tumors). The peptide is conjugated to hydrazinonicotinamide (HYNIC) to facilitate radiolabeling with technetium-99m (99mTc) for single-photon emission computed tomography (SPECT) imaging. Preclinical studies in breast cancer mouse models (MCF-7 and MDA-MB-231) have demonstrated rapid blood clearance, renal excretion, and high tumor uptake, highlighting its potential as a diagnostic imaging agent.
- Other names
- 99mTc-HYNIC-cRGDfk-NPY[99mTc]HYNIC-cRGDfk-NPY
02
Targets
NPY2R (Neuropeptide Y receptor subtype 2)NPY1R (Neuropeptide Y receptor Y1)αVβ3 (Integrin αVβ3)αVβ5 (Integrin αVβ5)
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