Drug intelligence / Profile preview

hyoscine butyl bromide + lidocaine

Development stage
Phase 2
Lead developer
Sanofi
Modality
Small Molecules
Administration
Intramuscular, Intravenous, Subcutaneous, Rectal
01

Overview

Hyoscine butyl bromide + lidocaine is a combination drug consisting of two active pharmaceutical ingredients: - **Hyoscine butyl bromide** (also known as scopolamine butylbromide or HBB) is an anticholinergic agent that acts primarily as a peripherally selective muscarinic receptor antagonist. It relaxes smooth muscle in the gastrointestinal and genitourinary tracts by blocking acetylcholine at muscarinic receptors, leading to spasmolytic and analgesic effects. It does not cross the blood-brain barrier due to its quaternary ammonium structure[1][2][6]. - **Lidocaine** is a local anesthetic of the amide type that works by blocking voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting nerve impulse conduction and providing local anesthesia. The combination may be used for conditions where both smooth muscle relaxation (antispasmodic effect) and local anesthesia are desired—such as certain diagnostic procedures or pain management scenarios involving abdominal or pelvic organs. The specific indications for this exact combination are not widely documented in major formularies; however, both agents are well-established individually for their respective uses.

Other names
hyoscine N-butylbromide + lidocainescopolamine butylbromide + lidocaineHBB + lidocaine
02

Targets

CHRM2 (M2)CHRM3 (M3)Nicotinic Acetylcholine ReceptorSCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)

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