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Hyper-sialylated human IgG m234
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
**Hyper-sialylated human IgG m234** is an engineered hyper-sialylated form of human immunoglobulin G designed to enhance anti-inflammatory effects beyond standard IVIg therapy. It features increased sialylation on the Fc domain, which upregulates inhibitory FcγRIIb on effector cells like macrophages and B cells, reduces binding to activating Fcγ receptors, and attenuates proinflammatory responses. Developed by Momenta Pharmaceuticals (acquired by Janssen/Johnson & Johnson), it aims to treat autoimmune diseases such as immune thrombocytopenia purpura (ITP) at lower doses with improved efficacy and tolerability compared to conventional high-dose IVIg.
- Other names
- M254M-254M 254
02
Targets
CD209 (Dendritic cell-specific intercellular adhesion Molecule-3-Grabbing non-integrin)FCGR2B (Fc gamma receptor IIB)FCER2 (Low affinity immunoglobulin epsilon fc receptor)SIGNR1 (CD209 antigen-like protein B)
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