Drug intelligence / Profile preview

hypericum extract LI160

Development stage
Preclinical
Lead developer
Advance Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Hypericum extract LI160 is a standardized pharmaceutical-grade preparation of St. John's wort (Hypericum perforatum), developed and produced by Lichtwer Pharma. It is typically extracted from dried aerial parts of the plant and standardized to contain 0.3% hypericin derivatives, with capsules usually containing 300 mg of the extract. The product is primarily indicated for the treatment of mild to moderate depression and has been studied in various clinical trials for its antidepressant effects. Its mechanism of action is not fully defined but involves multiple bioactive constituents such as hypericin, pseudohypericin, and hyperforin, which may influence neurotransmitter systems including serotonin, dopamine, and norepinephrine pathways[1][5][6].

Brand names
LI 160LI160LI-160
Other names
St John's Wort - Lichtwer PharmaHypericum perforatum extract LI160Hypericum extract LI 160
02

Targets

SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)

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