hypericum extract WS 5570

Hypericum extract WS 5570 is a standardized dry herbal extract derived from the flowering tops of *Hypericum perforatum* (St. John’s wort). It is produced using an extraction solvent of methanol (80% v/v) with a drug-to-extract ratio of approximately 3–7:1[7]. The main active constituents are believed to be hyperforin and hypericin, which contribute to its pharmacological effects. WS 5570 acts as an antidepressant and has demonstrated efficacy in multiple randomized controlled trials for the acute treatment of mild to moderate major depression, with some evidence supporting use in moderate to severe cases as well[1][2][3][6]. Its mechanism involves inhibition of the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine in the central nervous system. The safety profile is favorable; adverse event rates are similar to placebo and lower than those seen with synthetic antidepressants like paroxetine[1][3]. WS 5570 is approved for use in Germany for depression treatment and has been studied both for acute episodes and continuation/maintenance therapy after recovery from depression[1]. Caution is advised when used alongside other medications due to potential drug interactions mediated by induction or inhibition of cytochrome P450 enzymes and P-glycoprotein transporters[4].

Brand names

WS 5570WS5570WS-5570

Other names

Hypericum extract WS 5570St. John's Wort extract WS 5570St. John's Wort (Chinese name: 圣约翰草)