Drug intelligence / Profile preview

hypericum perforatum extract

Development stage
Unknown
Lead developer
Permamed
Administration
Oral
01

Overview

Deprivita is a phytotherapeutic antidepressant developed and marketed by Permamed. It contains a quantified dry ethanolic extract of St. John's wort (*Hypericum perforatum*), standardized to hypericin. Deprivita is approved in Switzerland for the treatment of mild to moderate depressive episodes. The therapeutic effects of St. John's wort extract are primarily attributed to active constituents such as hyperforin and hypericin, which act by inhibiting the synaptosomal reuptake of key neurotransmitters, including serotonin, norepinephrine, and dopamine, thereby elevating their levels in the synaptic cleft.

Brand names
Deprivita
Other names
Hyperici herbae extractum ethanolicum siccumSt. John's wort extract
02

Targets

SERT (Sodium-dependent serotonin transporter)DAT (Dopamine plasma membrane transport protein)PXR (Pregnane X receptor)NET (Norepinephrine Transporter)

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