hypericum polyanthemum extract

**Hypericum polyanthemum extract** is a botanical product derived from the South Brazilian plant species *Hypericum polyanthemum*, a member of the Hypericum genus (which includes St. John's Wort)[1][3][4]. Extracts from this species have demonstrated a variety of biological activities in preclinical studies, including **antidepressant-like effects**, **antinociceptive (pain-reducing) effects**, **anti-Trichomonas vaginalis activity**, and **leishmanicidal activity**[1][4]. The major chemical constituents generally belong to classes such as **acylphloroglucinols, xanthones, benzophenones, and flavonoids**[3]. Mechanistically, these extracts act via multiple targets: modulation of monoamine neurotransmitters (e.g., serotonin and noradrenaline), inhibition of monoamine oxidase, acetylcholinesterase inhibition, antioxidant activity (reducing oxidative stress and reactive oxygen species), and antimicrobial activities by inhibiting bacterial and protozoal growth[3][4]. The extract is typically investigated as an oral formulation in animal models, and safety has been supported at lower doses, although high doses can affect liver function and body weight[1]. The extract is not an approved pharmaceutical drug, but is considered a natural product with potential for use as a **dietary supplement or herbal medicine**.

Brand names

hypericum polyanthemum extract

Other names

Hypericum polyanthemum extractH. polyanthemum extractHypericum polyanthemum cyclohexane extractHypericum polyanthemum supercritical fluid extract