hyperinsulinemic normoglycemic clamp

The hyperinsulinemic normoglycemic clamp is a metabolic intervention protocol developed and evaluated by the McGill University Health Centre (MUHC) to improve outcomes in patients undergoing major liver resection. The protocol involves the continuous intravenous infusion of high-dose insulin (typically 2 mU/kg/min) alongside a titrated dextrose (glucose) infusion to maintain normal blood glucose levels while achieving high systemic insulin concentrations. This technique aims to optimize hepatic glycogen stores, which are often depleted during surgical stress, thereby reducing hepatocellular apoptosis and modulating the inflammatory response. Clinical research, including the NCT00774098 trial, has demonstrated that this perioperative support can significantly reduce postoperative liver dysfunction, surgical site infections, and other major postoperative complications.

Other names

glucose-insulin clamp protocolhyperinsulinemic normoglycemic clamp protocol