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hyperpolarized carbon 13 alpha-ketoglutarate
- Development stage
- Phase 1
- Lead developer
- University of California, San Francisco
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Hyperpolarized carbon-13 alpha-ketoglutarate (HP 13C-aKG) is an investigational metabolic imaging probe used in magnetic resonance (MR) spectroscopic imaging. It is specifically designed to non-invasively detect the metabolic activity of isocitrate dehydrogenase (IDH) mutations in glioma. In IDH-mutant cells, the enzyme reduces alpha-ketoglutarate to the oncometabolite 2-hydroxyglutarate (2-HG). By using hyperpolarization to enhance the carbon-13 signal, HP 13C-aKG allows for real-time monitoring of this conversion, providing a tool to characterize tumor burden and metabolic state. It is currently being evaluated in early-phase clinical trials led by investigators at the University of California, San Francisco, in collaboration with the National Cancer Institute.
- Other names
- hyperpolarized carbon-13 alpha-ketoglutaratehyperpolarized 13C-aKGhyperpolarized13C-aKGhyperpolarized-13C-aKGhyperpolarized [1-13C]alpha-ketoglutarate
02
Targets
IDH1 (Isocitrate dehydrogenase [NADP] cytoplasmic)2OGDD (Alpha-ketoglutarate-dependent dioxygenase)IDH2 (Isocitrate dehydrogenase [NADP], mitochondrial (mutant))
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