Drug intelligence / Profile preview

hypoallergenic 6 grass and rye pollen allergoid extract

Development stage
Unknown
Lead developer
Allergopharma
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

Allergovit is a subcutaneous allergen immunotherapy (SCIT) product developed by Allergopharma Joachim Ganzer KG. It consists of a hypoallergenic allergoid extract derived from a mixture of six grass pollen species (*Holcus lanatus*, *Dactylis glomerata*, *Lolium perenne*, *Phleum pratense*, *Poa pratensis*, and *Festuca pratensis*) and rye pollen (*Secale cereale*). The allergens are chemically modified with formaldehyde to reduce their IgE-binding capacity (allergenicity) while preserving their ability to induce a protective immune response (immunogenicity). The extract is co-precipitated with aluminium hydroxide, which acts as an adjuvant to provide a depot effect for sustained release. It is indicated for the treatment of IgE-mediated allergic rhinitis, allergic conjunctivitis, and allergic asthma induced by grass and rye pollen, typically administered in a preseasonal regimen to induce immune tolerance.

Brand names
Allergovit
Other names
6-grass plus rye pollen allergoidAllergovit 6-grass/rye
02

Targets

Allergen-specific IgE antibodies to grass pollen allergensHLA-DR (Human leukocyte antigen DR)

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