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hypoimmune EHM
- Development stage
- Preclinical
- Lead developer
- Sana Biotechnology
- Modality
- iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies, Gene Therapies
- Administration
- Intravenous, Intraportal, Intratumoral, Implantation
01
Overview
Hypoimmune EHM refers to a genetically engineered cell therapy platform designed to evade immune rejection in allogeneic transplantation. The "hypoimmune" approach involves modifying cells—such as induced pluripotent stem cells (iPSCs)—to disrupt expression of major histocompatibility complex (MHC) class I and II molecules, thereby preventing recognition by the adaptive immune system, and overexpressing CD47 to inhibit innate immune responses from macrophages and natural killer (NK) cells. This technology aims to enable off-the-shelf cell therapies without the need for immunosuppression, with potential applications in diseases such as cancer, type 1 diabetes, and regenerative medicine. Sana Biotechnology is a leading developer of this platform.
- Other names
- hypoimmune EHM
02
Targets
MHC I (MHC class I})MHC II (Major histocompatibility complex class II receptor)SIRPA (Signal-regulatory protein alpha)
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