Drug intelligence / Profile preview

Hypovolol

Development stage
Unknown
Lead developer
Barakat Pharmaceutical Industries
Modality
Small Molecules
Administration
Oral
01

Overview

Hypovolol is an antihypertensive medication containing nebivolol, a third-generation, highly selective beta-1 adrenergic receptor antagonist. Developed and marketed by the Syrian company Barakat Pharmaceutical Industries, it is indicated for the treatment of hypertension. Nebivolol is distinguished from older beta-blockers by its dual mechanism of action: it reduces blood pressure by decreasing heart rate and myocardial contractility through beta-1 blockade, and it promotes vasodilation by stimulating the release of nitric oxide from the vascular endothelium via the L-arginine/nitric oxide pathway. This results in a reduction of peripheral vascular resistance. Hypovolol is available in oral tablet form in strengths ranging from 2.5 mg to 20 mg.

Brand names
Hypovolol
Other names
nebivolol
02

Targets

ADRB3 (β3)NOS3 (eNOS)ADRB1 (β1)

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