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hyssopus cuspidatus volatile oil

Development stage: Preclinical
Lead developer: Dingyuan Biomedical Technology
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Vaginal

Overview

Hyssopus cuspidatus volatile oil (HVO), also referred to by the sponsor code SXC, is a natural product extract derived from *Hyssopus cuspidatus Boriss.*, a plant used in traditional Uyghur medicine. The oil is a complex mixture of monoterpenes, sesquiterpenes, alcohols, hydrocarbons, and ketones, with major constituents including berbenone, β-pinene, pinocamphone, and eucalyptol. HVO is being investigated for its potential in treating respiratory conditions, particularly steroid-resistant asthma (SRA) and allergic asthma, as well as vulvovaginal candidiasis (VVC). Its mechanism of action involves the inhibition of neutrophil extracellular traps (NETs) formation by targeting neutrophil elastase, and the modulation of several inflammatory signaling pathways, including PI3K/Akt/JNK/P38 and TLR4/NF-κB/NLRP3. The compound is currently in the preclinical research stage and is being studied by various institutions in China, with material provided by Dingyuan Biomedical Technology.

Other names: HVOHyssopus cuspidatus Boriss. volatile oil

Targets

AKT (RAC-alpha serine/threonine-protein kinase)ELANE (Human Neutrophil Elastase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)RK (Ribokinase)TLR4 (Toll-like receptor 4)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)JNK (Mitogen-activated protein kinase kinase kinase family)

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