I-125-OI5V

I-125-OI5V (also known as 125I-OI5V or 125I-2-[4-(2-iodophenyl)piperidino]cyclopentanol) is a radiolabeled vesamicol analog with a five-membered ring structure that acts as a highly selective imaging probe for the sigma-1 receptor (σ1R). Developed by researchers at Kanazawa University, this single-photon emission computed tomography (SPECT) tracer is designed to non-invasively map and monitor the spatiotemporal expression of σ1R, which is upregulated in response to cellular stress such as myocardial ischemia and reperfusion injury, as well as doxorubicin-induced cardiotoxicity. By binding selectively to σ1R, I-125-OI5V serves as a valuable diagnostic tool in preclinical research to evaluate the severity of ischemic burden and assess myocardial viability.

Other names

125I-2-[4-(2-iodophenyl)piperidino]cyclopentanol125I-OI5V125I-labeled 2-[4-(2-iodophenyl)piperidino]cyclopentanolI-125-labeled OI5VI125-labeled OI5VI 125-labeled OI5VI-125iodophenyl-piperidino-cyclopentanolI125iodophenyl-piperidino-cyclopentanolI 125iodophenyl-piperidino-cyclopentanolI-125iodophenyl-piperidino-cyclopentanoneI125iodophenyl-piperidino-cyclopentanoneI 125iodophenyl-piperidino-cyclopentanone