I-BOP

I-BOP is a highly potent, selective agonist of the thromboxane A2 (TXA2) / prostaglandin H2 (PGH2) receptor (TP receptor). It is widely used as a pharmacological research tool to study thromboxane receptor-mediated pathways, including platelet aggregation, vascular smooth muscle contraction, and more recently, its role in skeletal muscle glucose uptake and whole-body glucose homeostasis. In preclinical studies, I-BOP has been shown to stimulate glucose uptake, oxidation, and glycogen synthesis in skeletal muscle cells, and to improve glucose tolerance in mouse models. It is primarily sold as a research-use-only reagent.

Other names

(5Z)-7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-hydroxy-4-(4-iodophenoxy)-1-buten-1-yl]-7-oxabicyclohept-2-yl]-5-heptenoic acid7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-hydroxy-4-(4-iodophenoxy)-1-butenyl]-7-oxabicyclohept-2-yl]-5z-heptenoic acid[1S-(1-alpha,2-beta(5Z),3-alpha(1E,3R*),4-alpha)]-7-[3-(3-hydroxy-4-(4'-iodophenoxy)-1-butenyl)-7-oxabicycloheptan-2-yl]-5-heptenoic acid