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i-FACTOR
- Development stage
- Phase 4
- Lead developer
- Cerapedics
- Modality
- Peptides, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
- Administration
- Surgical Implantation
01
Overview
i-FACTOR is a peptide-enhanced bone graft indicated for use in skeletally mature patients undergoing reconstruction of a degenerated cervical disc at one level (C3-C4 to C6-C7) following single-level discectomy for intractable radiculopathy or myelopathy. It is the first spinal bone graft powered by the P-15 Osteogenic Cell Binding Peptide, which synthetically replicates a segment of type I collagen that facilitates cellular attachment in connective tissues. The mechanism involves the surface-bound P-15 peptide chemically bound to calcium phosphate particles, attracting and activating bone-forming cells to promote bone growth and fusion. i-FACTOR is FDA approved as a Class III device for single-level anterior cervical discectomy and fusion (ACDF), demonstrating high fusion rates and statistical superiority over local autograft in clinical trials[1][2][4][5][6].
- Brand names
- i-FACTORi-FACTOR Peptide Enhanced Bone GraftP-15 Peptide Enhanced Bone GraftP15 Peptide Enhanced Bone GraftP 15 Peptide Enhanced Bone Graft
- Other names
- i-FACTORi-FACTOR Peptide Enhanced Bone GraftP-15 Peptide Enhanced Bone GraftP15 Peptide Enhanced Bone GraftP 15 Peptide Enhanced Bone Graft
02
Targets
ITGA2/ITGB1 (Integrin alpha-2/beta-1 receptor)COL1A2 (Type I collagen alpha-2 chain)
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