Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
I301 ASPIRE-T
- Development stage
- Unknown
- Lead developer
- TCRCure Biotech
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intrathecal, Intratumoral
01
Overview
I301 ASPIRE-T (also known as TC-I301) is an autologous chimeric antigen receptor T-cell (CAR-T) therapy targeting interleukin-13 receptor subunit alpha-2 (IL-13Rα2). Developed by TCRCure Biotech using its proprietary ASPIRE-T platform, the therapy is designed to treat brain cancers, specifically recurrent or refractory malignant gliomas. The ASPIRE-T platform redirects the TCR/CD3 complex to overcome the limitations of conventional CAR-T and TCR-T therapies, aiming to deliver a robust, sustained, and safer immune response against solid tumors. I301 ASPIRE-T is currently being evaluated in a Phase 1 clinical trial (NCT06355908) to assess its safety, tolerability, and efficacy in patients with recurrent or refractory grade 4 glioma.
- Other names
- IL-13Rα2 CAR-TIL-13Rα2 CAR-T cell therapyIL13Ra2 CAR-TIL-13Ra2 CAR-TIL 13Ra2 CAR-T
02
Targets
IL13RA2 (Interleukin-13 receptor subunit alpha 2)
Beyond the preview
Go deeper on I301 ASPIRE-T.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on I301 ASPIRE-T.