IAA-Cu-phen

**IAA-Cu-phen** is an experimental ternary copper(II) coordination complex comprising indole-3-acetic acid and 1,10-phenanthroline. In preclinical studies using MDA-MB-231 human breast cancer cells, it inhibited the chymotrypsin-like activity of the 20S proteasome, with molecular-docking results supporting interaction with the proteasome beta-5 catalytic subunit. Proteasome inhibition was associated with accumulation of ubiquitinated proteins, apoptotic signaling, and tumor-cell death. It has not been established as a clinically developed or marketed medicine.

Other names

IAA-Cu-PHENindole-3-acetic acid-copper(II)-1,10-phenanthroline complex