IADA-7

IADA-7 is a novel, non-nucleoside adenosine deaminase (ADA) inhibitor isolated from the soil bacterium *Bacillus sp.* J-89. Chemically identified as 2-N-methyl-2,4-diazacycloheptanone, it features a unique seven-membered diazacycloheptanone ring structure that distinguishes it from conventional purine-analog ADA inhibitors like pentostatin or coformycin. IADA-7 functions by inhibiting the hydrolytic breakdown of adenosine into inosine, a critical step in purine metabolism. Preclinical studies have demonstrated that IADA-7 exerts dose-dependent anti-proliferative activity and induces apoptosis in human cancer cell lines, specifically Jurkat T cells and J82 transitional-cell bladder carcinoma cells. Its discovery suggests potential therapeutic applications in oncology, lymphoproliferative disorders, and viral infections such as HIV and Hepatitis C.

Other names

2-N-methyl-2,4-diazacycloheptanone