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IB Complex
- Development stage
- Preclinical
- Lead developer
- HL Science
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
IB Complex is a proprietary nutraceutical complex developed by HL Science, composed of Indian gooseberry (*Phyllanthus emblica*) extract and barley sprout (*Hordeum vulgare*) extract. It is primarily designed for skin health and the management of metabolic disorders. In dermatological applications, IB Complex promotes skin rejuvenation by activating the TGF-β/Smad3 signaling pathway to enhance collagen synthesis and by inhibiting matrix metalloproteinases (MMP-1, MMP-3, and MMP-9) and the JNK/c-FOS/c-Jun pathway to prevent collagen degradation and wrinkle formation. Additionally, it has been shown to activate moisturizing factors such as serine palmitoyltransferase (SPT) and sphingolipid delta(4)-desaturase (DEGS1). IB Complex also possesses anti-inflammatory properties, reducing the expression of pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6, which supports its potential use in treating metabolic syndrome, obesity, and diabetes.
- Brand names
- IB Complex
- Other names
- Indian gooseberry and barley sprout complexIndian gooseberry and barley sprout extract complexIB-Complex
02
Targets
MMP3 (Matrix metalloproteinase-3)IL-6 (Interleukin 6)MMP9 (Matrix metalloproteinase-9)JNK (Mitogen-activated protein kinase kinase kinase family)IL1B (Interleukin-1 beta)MMP1 (Matrix metalloproteinase-1)TNFA (Tumor necrosis factor alpha (soluble))TGFBR1DEGS1 (Delta(4)-desaturase, sphingolipid 1)SPT (Serine palmitoyltransferase)
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