Drug intelligence / Profile preview

IB-Relieve

Development stage
Unknown
Lead developer
Integrative Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

IB-Relieve is a dietary supplement formulated to support gastrointestinal health and alleviate symptoms associated with Irritable Bowel Syndrome (IBS), such as abdominal pain, bloating, and gas. Developed by Integrative Therapeutics, the product contains a synergistic blend of enteric-coated essential oils, including peppermint oil, oregano oil, and ginger extract. Peppermint oil, the primary active component, acts as a smooth muscle relaxant in the gastrointestinal tract by inhibiting L-type calcium channels, thereby reducing spasms. Oregano oil provides antimicrobial properties that may help maintain a healthy balance of intestinal microflora, while ginger extract acts on serotonergic receptors (5-HT3 and 5-HT4) to support gastric motility and reduce nausea. The enteric coating is a critical formulation feature, ensuring that the volatile oils bypass the stomach to be released in the small intestine, which minimizes the risk of gastroesophageal reflux and heartburn.

Brand names
IB-Relieve
02

Targets

HTR4 (5-Hydroxytryptamine receptor 4)HTR3A (5-hydroxytryptamine receptor 3A)LTCC (Voltage-gated calcium channel (L-type))

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